https://researchberg.com/index.php/rrst <p>ResearchBerg Review of Science and Technology (<strong>RRST</strong>) is a peer-reviewed, open-access journal that publishes research articles, reviews, and technical reports in the fields of science and technology. It covers current and relevant advancements in science and technology across several disciplines.</p> <p><strong>Peer-Review Policy for the ResearchBerg Review of Science and Technology</strong></p> <p><strong>1. Purpose and Scope</strong></p> <p>The peer-review process is essential for maintaining the quality and integrity of published research in the <em>"ResearchBerg Review of Science and Technology."</em> This policy outlines the process, criteria, and ethical considerations to ensure that all submitted works undergo a rigorous and fair evaluation.</p> <p><strong>2. Initial Manuscript Assessment</strong></p> <p>All manuscripts submitted to the journal will first undergo an initial assessment by the editorial team. This step ensures that the submission aligns with the journal's scope, follows the prescribed formatting, and adheres to ethical guidelines.</p> <p><strong>3. Selection of Reviewers</strong></p> <p>For each manuscript that passes the initial assessment, the editorial team will select a minimum of two external reviewers with expertise in the relevant field. Reviewers are chosen based on their academic credentials, publication record, and the absence of any potential conflicts of interest with the authors.</p> <p><strong>4. Double-Blind Review Process</strong></p> <p>To eliminate potential biases, the journal adopts a double-blind review process. This means that both the authors and the reviewers remain anonymous to each other throughout the evaluation phase.</p> <p><strong>5. Review Criteria</strong></p> <p>Reviewers are provided with a standardized evaluation form that addresses the following key criteria:</p> <ul> <li>Originality and significance of the research.</li> <li>Clarity and coherence of the research question or hypothesis.</li> <li>Adequacy and appropriateness of the methodology.</li> <li>Accuracy and relevance of data analysis.</li> <li>Soundness of conclusions drawn.</li> <li>Relevance and adequacy of citations.</li> <li>Overall contribution to the field.</li> </ul> <p><strong>6. Reviewer Recommendations</strong></p> <p>After assessing the manuscript, reviewers can make one of the following recommendations:</p> <ul> <li>Accept without revisions.</li> <li>Accept with minor revisions.</li> <li>Revise and resubmit (major revisions required).</li> <li>Reject due to specific deficiencies or irrelevance.</li> </ul> <p><strong>7. Decision-making</strong></p> <p>The editorial team consolidates reviewer feedback and makes the final decision regarding the manuscript's status. The corresponding author will receive a decision letter, which includes reviewer comments and, if applicable, instructions for revisions.</p> <p><strong>8. Revision Process</strong></p> <p>If revisions are required, authors are expected to address each point raised by the reviewers. A revised manuscript should be accompanied by a detailed response letter that outlines the changes made and provides justification for any points not addressed.</p> <p><strong>9. Post-Acceptance and Publication</strong></p> <p>Manuscripts accepted for publication will undergo a final proofreading and formatting phase. Authors may be contacted to clarify any ambiguities or address minor issues.</p> <p><strong>10. Ethical Considerations</strong></p> <p>All participants in the peer-review process are expected to adhere to the highest ethical standards. This includes:</p> <ul> <li>Reviewers should disclose any potential conflicts of interest and recuse themselves if necessary.</li> <li>Reviewers should treat manuscripts confidentially and not use the knowledge gained for personal advantage.</li> <li>Authors should respect feedback, even if they disagree, and engage constructively.</li> </ul> <p><strong>11. Appeals Process</strong></p> <p>If authors disagree with the decision, they have the right to appeal by providing a detailed rationale. The editorial board will re-assess the manuscript and the reviews, potentially seeking an additional opinion if deemed necessary.</p> <p><strong>Editor-in-chief</strong></p> <p><a href="https://www.amu.ac.in/faculty/geography/rashid-aziz-faridi" target="_blank" rel="noopener">Dr. Rashid Aziz Faridi</a></p> <p>Professor</p> <p>Aligarh Muslim University, India</p> <p> </p> ResearchBerg en-US ResearchBerg Review of Science and Technology https://researchberg.com/index.php/rrst/article/view/220 <p>Neuropathic pain is a chronic condition that arises from damage or dysfunction within the somatosensory nervous system, characterized by persistent pain, hyperalgesia, and allodynia. Recent research has highlighted the role of epigenetic modifications in the regulation of gene expression that contributes to the development and persistence of neuropathic pain and associated neuronal injury. Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, influence the transcriptional landscape of neurons and glial cells in response to nerve injury. These modifications can lead to changes in the expression of genes involved in inflammation, synaptic plasticity, ion channel function, and neuroimmune interactions, which play critical roles in maintaining pain states. DNA methylation, particularly at promoter regions, can suppress or enhance the expression of pain-related genes, while histone modifications, such as acetylation and methylation, can alter chromatin structure to regulate gene accessibility. Non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), further modulate post-transcriptional gene expression, affecting the function of key signaling pathways. This review provides a comprehensive analysis of the epigenetic mechanisms involved in neuropathic pain and neuronal injury, exploring their roles in gene expression changes that contribute to pain sensitization and chronicity. We also discuss potential therapeutic strategies targeting epigenetic regulators to reverse maladaptive gene expression changes and alleviate chronic pain. Understanding the interplay between epigenetics and gene expression in neuropathic pain may lead to novel approaches for managing this challenging condition and improving patient outcomes.</p> Kritchai Sukprasert Wichai Phadungkit Copyright (c) 2024 Authors https://creativecommons.org/licenses/by-nc-nd/4.0 2024-09-04 2024-09-04 4 9 1 10